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KMID : 0380020180330010019
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Korean Journal of Biotechnology and Bioengineering
2018 Volume.33 No. 1 p.19 ~ p.25
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The Evaluation of Niacinamide-dipeptide Convergence as Skin Whitening Materials
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Kim Ga-Yeon
Lee Seung-Je
Jeon Mi-Ji
Kim Bo-Min
Kim Geun-Tae
Kang Sang-Moon
Lee Kee-Young
Shin Eun-Jin
Kim Sang-Yong
Kim Young-Min
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Abstract
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The purpose of this study was to investigate the skin-whitening effects of Niacinamide-dipeptide Convergence (Niacin-peptide). To evaluate skin-whitening effects of Niacin-peptide, we performed tyrosinase inhibition assay and L-DOPA oxidation inhibition assay. These results demonstrated that Niacin-peptide decreased melanin production through tyrosinase inhibition. Also, we measured expression level of melanogenesis-related mRNA and proteins by reverse transcription-polymerase chain reaction (PCR) and western blotting. Results of PCR and Western blotting were showed that Niacin-peptide reduced expression of microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP-2) and tyrosinase. Thus, we identified the skin-whitening effect of Niacin-peptide and this finding demonstrated that Niacinamide-dipeptide Convergence may have potential as cosmetic ingredient.
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KEYWORD
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niacin-dipeptide convergence, niacin-peptide, skin whitening, anti-melanogenic
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